gue clásico (FD) en pacientes con B*57, una susceptibilidad disminuida al 1Laboratorio de Fisiopatología, Instituto Venezolano de Investigaciones Científicas. ARTIGO DE REVISÃO. Dengue e dengue hemorrágico: aspectos do manejo na unidade de terapia intensiva. Sunit SinghiI; Niranjan KissoonII; Arun BansalI. A dengue hemorrágica é manifestação rara e ocorre quase que exclusivamente em pacientes com experiência anterior, sugerindo fisiopatologia associada a.
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SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal’s impact. SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. In endemic areas, a small proportion of individuals infected with dengue virus develop dengue hemorrhagic fever DHF suggesting that there may be host specific resistance factors playing an important role.
This work describes the frequency of HLA class I and class II alleles in patients with dengue and the relationship with the clinical manifestations of the disease. Dengue virus infections are an important cause of morbidity and mortality in tropical and subtropical areas 1.
In humans, the infection can be asymptomatic or can result in a variable range of clinical syndromes, including classical dengue fever DF and the more severe form of disease known as dengue hemorrhagic fever DHF 2. In Venezuela, the dengue virus serotypes 1, 2 and 4 are endemic, they circulate simultaneously throughout the year in the largest cities 3however severe epidemics of dengue or DHF in Venezuela have been shown to be the result of the introduction of dengue virus serotype 3 in Several hypotheses have been postulated to explain the pathogenesis of severe dengue disease, with immunopathogenesis as the most supported model.
It has been suggested that polymorphisms in the cytokine genes may play an important role in the pathogenesis of DHF 5. However, other immune response-related genes e. HLA genesas well as non-genetic factors such as dengue virus serotype and host viral burden, must also be considered. The association of DHF with HLA antigens has been reported in ethnically and geographically distinct populations 6— Whole blood was collected from 77 unrelated patients mean age 27, range years.
Using all available clinical and laboratory data, 73 of the 77 patients were classified into two different clinical groups: Six patients, albeit infected with dengue virus, were not clinically classified. All patients were ethnically mixed Venezuelans, i. A previous study using genetic markers has shown that the origin of genes carried by the central urban Venezuelan population is approximately However, antibody concentrations in serum were not registered in the clinical history of the patients.
The clinical diagnosis was confirmed in accordance with the World Health Organization WHO criteria 2using all available clinical and laboratory data. They were clinically denghe as patients with dengue fever DFan acute febrile illness with two or more of the following manifestations: It was not possible as part of this study to determine the serotype of the dengue virus.
One hundred-twenty seven unrelated healthy subjects of similar ethnic background and without signs of infection were tested as controls. A local ethics committee approved the research protocol. Genomic DNA was extracted from blood samples using a modified salting-out procedure Allele and genotype frequencies were determined by direct counting.
The OR is used to estimate risk in casecontrol studies in which the relative risk calculations is not appropriate. The analysis of Clasivo I profiles in the patient and control groups showed three significant associations. HLA-class I specificities with frequency differences among patients with dengue infection DI; entire group and control subjects, and patients with dengue fever DF versus patients with dengue hemorrhagic fever DHF.
Dengue: cardiac manifestations and implications in antithrombotic treatment
Results are presented as phenotype frequency percent. However, all of these HLA class I frequency denguue lost significance after Bonferroni correction. HLA-DRB1 specificities with frequency differences clasixo patients with dengue infection DI; entire group and control subjects, patients with dengue fever DF versus control and patients with dengue hemorrhagic fever DHF versus healthy individuals.
Dengue virus infection has emerged as one of the most important arthropod-borne diseases. It is well documented that viral burden and infected cell mass determine the clinical severity of dengue infections; however, the ability of the host to recognize and process antigens to produce antibodies or the fisiopatoologia immune response during dengue infection could be under genetic control 4.
More recently, Lan et al. Furthermore, a positive association of HLA-DQ1 and susceptibility to classical dengue fever in a white Southern Brazilian population has been reported The present study is the first to examine a complete set of HLA polymorphisms and to determine all class I and class II alleles in infected Venezuelan individuals using molecular methods.
The preliminary results of our study among patients with dengue virus infection have shown several positive and deengue associations, suggesting either predisposing or protective effects of MHC genes on the development of the infection. The fisiopatllogia suggest that polymorphism in the HLA class I and II genes may be associated with genetically diminished and enhanced susceptibility to the development of dengue virus infection and with disease severity DHF in the studied population.
It is possible that the pathogenesis of dengue hemorrhagic fever may involve different HLA specificities together with other non-HLA gene families. The clxsico to assess several polymorphisms throughout the human genome may provide insights into possible mechanisms of ddngue and protection in dengue Meanwhile, the genetic background of the host, the viremia titer, the antibody response pattern and virus serotype seem to be correlated with disease severity.
The authors declare no financial conflict of interest. Previous article Next article. April – June Pages This item has received. Show more Show less.
OPS/OMS | Dengue: Información general
In Venezuela, the dengue virus serotypes 1, 2 and 4 are endemic, they circulate simultaneously throughout the year in the largest cities 3however severe epidemics of dengue or DHF in Venezuela have been shown to be the result of the introduction of dengue virus serotype 3 in 4.
HLA genesas well as non-genetic factors such as dengue virus serotype and host viral burden, must also be considered.
Six patients, albeit infected with dengue virus, were not clinically classified. It was not possible as part of this study to determine the serotype of the dengue virus.
A local ethics committee approved the research protocol. Statistical Analysis Allele and genotype frequencies were determined by direct counting. Rev Med Microbiol, 6pp. Prevention and Control, World Health Organization, Serotipos y genotipos de Virus Dengue circulantes en Venezuela, — Acta Cient Venez, 49pp. Curr Opinion Infect Dis, 15pp. Tissue Antigens, 64pp.
Histocompatibility Antigens and Dengue Hemorrhagic Fever. Am J Trop Med Hyg, 30pp. Haematologia, 20pp.
Advantages of the Cuban population for HLA studies of dengue virus infection. Hum Immunol, 68pp. Hum Immunol, 63pp.
Association of human leukocyte antigen DQ1 and dengue fever in a white Southern Brazilian population.
Mem Inst Oswaldo Cruz, 99pp. HLA-A and —B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais. Tissue Antigens, 60pp. Castro de Guerra, M. Interciencia, 26 sengue, pp. On estimating the relation between blood group and disease. Ann Hum Genet, 19pp. The estimation and significance of the logarithm of a ratio of frequencies. Ann Hum Genet, 20pp.
J Infect Dis,pp. Susceptibility to Dengue Hemorrhagic Fever in Vietnam: Am J Trop Med Hyg, 67pp.
Dengue: Información general
Immunology,pp. Hum Immunol, 55pp. Subscribe to our Newsletter. Print Send to a friend Export reference Mendeley Statistics.
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