LEY 29499 PDF

Alexander Zarbock, , Kai Singbartl, Klaus Ley. Alexander Zarbock, , Kai ;(12) View: Text | PDF. Journal Article, Research Support, N.I.H., Extramural DOI: /JCI The Digital Object Identifier (DOI) System enables identification of digital entities. Si contestas correctamente las 10 preguntas, ¬°felicitaciones, eres un fan con todas las de la ley! Y si no, al menos est√°s en camino.

Author: Gardasar Zulkim
Country: Suriname
Language: English (Spanish)
Genre: Finance
Published (Last): 7 September 2005
Pages: 151
PDF File Size: 12.64 Mb
ePub File Size: 3.31 Mb
ISBN: 205-2-25957-118-6
Downloads: 96440
Price: Free* [*Free Regsitration Required]
Uploader: Maulmaran

Either your web browser doesn’t support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

A comment on this article appears in ” Selectins revisited: Europe PMC requires Javascript to function effectively. No matching affiliation detected. Find all citations in this journal default.

Or filter your current search. The Journal of Clinical Investigation [01 Dec Abstract Acute lung injury ALI causes high mortality, but its molecular mechanisms are poorly understood.


Acid aspiration is a frequent cause of ALI, leading to neutrophil sequestration, increased permeability, and deterioration of gas exchange. We investigated the role of platelet-neutrophil interactions in a murine model of acid-induced ALI. Acid aspiration induced P-selectin-dependent platelet-neutrophil interactions in blood and in lung capillaries.

Reducing circulating platelets or blocking P-selectin halted the development of ALI. Bone marrow chimeras showed that platelet, not endothelial, P-selectin was responsible for the injury.

The interaction of platelets with neutrophils and endothelia 299499 associated with TXA 2 formation, with detrimental effects on permeability and tissue function.

Activated platelets induced endothelial expression of ICAM-1 and increased neutrophil adhesion. Inhibition oey platelet-neutrophil aggregation improved gas exchange, reduced neutrophil recruitment and permeability, and prolonged survival. The key findings were confirmed in a sepsis-induced model of ALI.

Results list of Browse by country – NATLEX

These findings may translate into improved clinical treatments for ALI. Read Article at publisher’s site. How does Europe PMC derive its citations network?


CitePeer Related Articles http: Gene Ontology GO Terms.