LEY 29499 PDF

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A comment on this article appears in ” Selectins revisited: Europe PMC requires Javascript to function effectively. No matching affiliation detected. Find all citations in this journal default.

Or filter your current search. The Journal of Clinical Investigation [01 Dec Abstract Acute lung injury ALI causes high mortality, but its molecular mechanisms are poorly understood.

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Acid aspiration is a frequent cause of ALI, leading to neutrophil sequestration, increased permeability, and deterioration of gas exchange. We investigated the role of platelet-neutrophil interactions in a murine model of acid-induced ALI. Acid aspiration induced P-selectin-dependent platelet-neutrophil interactions in blood and in lung capillaries.

Reducing circulating platelets or blocking P-selectin halted the development of ALI. Bone marrow chimeras showed that platelet, not endothelial, P-selectin was responsible for the injury.

The interaction of platelets with neutrophils and endothelia 299499 associated with TXA 2 formation, with detrimental effects on permeability and tissue function.

Activated platelets induced endothelial expression of ICAM-1 and increased neutrophil adhesion. Inhibition oey platelet-neutrophil aggregation improved gas exchange, reduced neutrophil recruitment and permeability, and prolonged survival. The key findings were confirmed in a sepsis-induced model of ALI.

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These findings may translate into improved clinical treatments for ALI. Read Article at publisher’s site. How does Europe PMC derive its citations network?

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CitePeer Related Articles http: Gene Ontology GO Terms.